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Natural Products Analysis Instrumentation, Methods, and Applications

  • Erscheinungsdatum: 17.09.2014
  • Verlag: Wiley
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Natural Products Analysis

This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. - Applies analytical techniques to natural products research – an area of critical importance to drug discovery - Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics - Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence - Covers instrumental techniques with enough detail for both current practitioners and beginning researchers Vladimir Havlicek is a Professor of Analytical Chemistry in the Institute of Microbiology of the Academy of Sciences of the Czech Republic. His laboratory uses analytical tools to characterize molecular structure. He has worked in the field of natural products for over 20 years. Dr. Havlicek is on the editorial or advisory boards of several leading analytical journals and has published over 130 papers in peer-reviewed journals. Jaroslav Spizek is a Professor of Molecular and Cell Biology and Genetics in the Institute of Microbiology of the Academy of Sciences of the Czech Republic, where he was director between1992-2000. He has worked in the field of antibiotics for 50 years. In 2011, he became an Elected Fellow of the American Academy of Microbiology. Professor Spizek has published 98 peer-reviewed papers and edited two books.


    Format: ePUB
    Kopierschutz: AdobeDRM
    Seitenzahl: 624
    Erscheinungsdatum: 17.09.2014
    Sprache: Englisch
    ISBN: 9781118876022
    Verlag: Wiley
    Größe: 24534 kBytes
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Natural Products Analysis

Chapter 1
Natural Products Analysis : Instrumentation, Methods, and Applications

Vladimír Havlíček and Jaroslav Spížek

Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

This book aims at highlighting the newest trends in analytical chemistry that have recently been, or soon will be, employed in the analysis of natural products and their complex mixtures. All contributing authors were motivated to stress the innovative aspects in emerging natural product chemistries and were asked to formulate their own personal visions clearly indicating which milestones can be achieved in their fields of expertise in a five-year frame. The book is structured according to analytical instrumental approaches used either routinely or experimentally for structure characterization and/or determination of both low- and high-molecular-weight natural products.

This book enumerates the most recent and cutting-edge analytical approaches including those that have not yet been commercialized into the rejuvenated natural products field. For example, less-traditional applications of synchrotron irradiation to small molecules are reported when referring to standard X-ray diffraction. Likewise, examples of the newest hyphenation techniques with impact on screening and secondary metabolism studies are described in cases in which well-known multidimensional NMR spectroscopy is discussed.

The revitalization of the natural product field is documented by an increase in the number of peer-reviewed articles illustrated by a Web of Science search ( Figure 1.1 ). The number of hits is seen to have increased threefold if the term "natural product activity" is evaluated. Antibacterial, antifungal, antineoplastic, anti-inflammatory, and other activities are also reported in patent literature. SciFinder returned constant data for the 2007–2013 period oscillating between 60 and 80 patent applications published annually. Diverse applications of natural products are also subjects of many review articles and book chapters. Interestingly, no monograph focused on instrumentation used for identification of natural products has been published in the past decade. This market gap was identified by Wiley senior editor Jonathan T. Rose: "In my opinion, given that plants and natural products are major sources for current and potential drugs, there is need for a book geared to researchers and professionals to facilitate natural product analysis, synthesis, and drug discovery. This type of book could explain the basics of natural products as pharmaceuticals, analytical tools and techniques, methods for isolation and elucidation, and applications for library design and in drug discovery. Such a book will find a welcome audience in organic and medicinal chemists, biochemists, analytical and medicinal chemists, microbiologists, and biomedical researchers."

Figure 1.1 Report of published items accessed from the Web of Knowledge (Thomson Reuters) on December 31, 2013 illustrates the number of papers published annually in the field of "Natural Product Structure."

In this book the instrumentation represents the common denominator. The contributors were motivated to make a very brief introduction to physicochemical principles of their methods and give an up-to-date overview of the most important applications relevant to natural products. In a limited number of chapters the tutorial part was extended, giving the reader the opportunity to get acquainted with both the fundamentals and future trends in one place. Personal views and mutual instrumental evaluations will help the newcomers to find a suitable technique. For instance, whereas nuclear magnetic resonance spectroscopy is nonselective and less sensitive (&ldq

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