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Ruthenium Complexes Photochemical and Biomedical Applications

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Ruthenium Complexes

Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of ruthenium-containing complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium-containing complexes and their synthesis, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium. The second part of the text covers biological properties and important medical applications of ruthenium-containing complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes, and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry. Alvin A. Holder is an associate professor at Old Dominion University in Norfolk, U.S.A. He graduated from the University of the West Indies, Barbados, with a B.Sc. and acquired his Ph.D. in inorganic chemistry with Prof. Tara P. Dasgupta. He was a faculty member at the University of the West Indies, Cave Hill Campus, Barbados, and an assistant professor in chemistry at the University of Southern Mississippi. His current research involves transition metal chemistry and he has published more than 60 articles and several textbooks and book chapters. In 2012, he was awarded an NSF Career Award. Lothar Lilge is a senior scientist at the Princess Margaret Cancer Centre and holds a professorship at the University of Toronto, Canada. He obtained his Diploma in physics from the Johann Wolfgang Goethe University in Frankfurt, Germany, and his Ph.D. degree in biophysics from the Westfaehlische Wilhelms University in Muenster, Germany. Additional training was provided through the Wellman Laboratories of Photomedicine at Massachusetts General Hospital, Boston, U.S.A., and during a post-doc at McMaster University in Hamilton, Canada. His work is focused on photodynamic therapy including the use of ruthenium-based photosensitizers and optical spectroscopy for diagnostic and risk assessment among a range of other biophotonic application in medicine. Wesley R. Browne is an associate professor at Stratingh Institute for Chemistry at the University of Groningen, The Netherlands, since 2013. He completed his Ph.D. degree at Dublin City University, Ireland, with Prof. J. G. Vos in 2002, followed by a postdoc under the joint guidance of Prof. J. G. Vos and Prof. J. J. McGarvey, Queens University Belfast, U.K. Between 2003 and 2007 he was a postdoctoral research fellow in the group of Prof. B. L. Feringa at the University of Groningen. He was appointed assistant professor in 2008. His current research interests include transition metal based oxidation catalysis, electrochromic materials and responsive surfaces. He is an advisory board member for the European Journal of Inorganic Chemistry, Particle & Particle Characterization (both Wiley) and Chemical Communications (RSC). He has (co-)authored over 150 research papers, reviews and book chapters. Mark A. W. Lawrence was a post-doctoral fellow at Old Dominion University in Norfolk, U.S.A., in the group of Prof. A. Holder. He received his B.Sc. degree in 2006 and his Ph.D. degree in inorganic-physical chemistry in 2011 from the University of the West Indies (UWI), Mona Campus, Jamaica, with Prof. Tara P. Dasgupta. His research interests include synthesis of hydrazones and functionalized pyridyl benzothiazoles, their transition metal complexes and application to catalysis and biological processes. Jimmie L. Bullock Jr. is a Ph.D. student at the University of Kentucky in Lexington, U.S.A. in the department o


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    Sprache: Englisch
    ISBN: 9783527695249
    Verlag: Wiley-VCH
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Ruthenium Complexes

Chapter 1
Karen J. Brewer (1961-2014): A Bright Star that Burned Out Far Too Soon

Seth C. Rasmussen

North Dakota State University, Department of Chemistry and Biochemistry, Fargo, ND, 58108-6050, USA
1.1 Introduction

Over the span of her career, first at Washington State University (WSU) and later at Virginia Tech, Karen J. Brewer ( Figure 1.1 ) earned international acclaim as a prolific and pioneering researcher in the photochemistry and photophysics of multimetallic complexes [1, 2]. Ranging from synthesis of new multimetallic complexes to the study of their ground- and excited-state properties, her contributions aimed to elucidate the effect of the specific assembly of such complexes on their respective spectroscopic and electrochemical properties. In the process, Karen studied the application of complexes to molecular photovoltaics, solar H2 production, artificial photosynthesis, electrocatalysis, Pt-based DNA binders, and photodynamic therapy [1-6]. Publishing her first paper in 1985, she accumulated over 125 peer-reviewed research publications in her career, which have in turn garnered over 3000 citations to date [1, 2], and her research pace was as active as ever at the time of her premature death in 2014 ( Figure 1.2 ) [1].

Figure 1.1 Karen J. Brewer (1961-2014) in the Spring of 2014.

(Courtesy of Virginia Tech.)

Figure 1.2 Publications per year from 1985 to 2015.

Although known specifically for her various research contributions, Karen was also an award-recognized educator. She was comfortable teaching chemistry at all levels, from first-year students in general chemistry to graduate students in special topics classes such as electrochemistry and the photophysics of transition metal complexes. Her enthusiasm in the classroom was infectious and she inspired students to change not only their view of chemistry but, in some cases, their major to chemistry [1].

For many, including this author, Karen will be remembered most for her role as mentor and role model. She had tremendous impact on everyone who transitioned through her research laboratory, from undergraduates to postdocs. Throughout her career, Karen was a strong advocate for women and minorities in chemistry and was a role model and mentor for many female students and researchers [1, 2, 5]. Her passion in the promotion of chemistry as a career choice for women was most evident in her extensive outreach efforts to K-12 students. Throughout her career, she regularly visited primary and secondary school classrooms and hosted students in her laboratories at Virginia Tech [1, 2, 5]. In the process, Karen provided a real-life role model for young girls and others with aspirations to work in the physical sciences [1, 5].

Over the years, Karen received significant recognition for her collective efforts in research, teaching, and outreach. This included a College of Arts and Sciences Diversity Award in 1996, shortly after arriving at Virginia Tech [1, 5], as well as various teaching awards [3] and a Popular Mechanics Breakthrough Innovator Award in 2010, which she shared with collaborator Dr Brenda Winkel [2-5]. Most recently, Virginia Tech recognized her outreach efforts with the 2014 Alumni Award for Outreach Excellence [1-4], which she shared with Dr Shamindri Arachchige, Virginia Tech instructor of chemistry and a former postdoctoral researcher from her research group [1, 5, 7].
1.2 Early Years

Karen Sonja Jenks was born on June 27, 1961, in Wiesbaden, Germany to parents Gerda and Henry Jenks [3, 4]. As the daughter of a career military man, Karen moved frequently in her youth ( Figure 1.3 ) [2-4], which provided her the opportunity to see much of the United States and the world as a young girl [3, 4]. The family ultimately settled in Lancaster, Sou

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