Mixed modeling is one of the most promising and exciting areas of statistical analysis, enabling the analysis of nontraditional, clustered data that may come in the form of shapes or images. This book provides in-depth mathematical coverage of mixed models' statistical properties and numerical algorithms, as well as applications such as the analysis of tumor regrowth, shape, and image. The new edition includes significant updating, over 300 exercises, stimulating chapter projects and model simulations, inclusion of R subroutines, and a revised text format. The target audience continues to be graduate students and researchers. An author-maintained web site is available with solutions to exercises and a compendium of relevant data sets. EUGENE DEMIDENKO, PhD, is Professor of Biostatistics and Epidemiology at the Geisel School of Medicine and Department of Mathematics at Dartmouth College. Dr. Demidenko carries out collaborative work at the Thayer School of Engineering, Dartmouth College, including nanocancer therapy and electrical impedance tomography for breast cancer detection. Dr. Demidenko is recipient of several awards from the American Statistical Association and has been an invited lecturer at several institutes and academies around the world.
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